59. Clanton, N. A.; Spiller, T. E.; Ortiz, E.; Frantz, D. E.; et. al. “A Metal-Free Reductive N-Alkylation of Indoles with Aldehydes.” Org. Lett., 2021, 23, 9, 3233-3236. Highlighted as a Supplementary Cover! Read it here!!

58. Schneider, J. A.; Frantz, D. E.; et. al. “Disregulated Ribonucleoprotein Granules Promote Cardiomyopathy in RBM20 Gene-Edited Pigs.” Nature Medicine202026, 1788. Read it here!!

57. Clanton, N. A.; Hastings, S. D.; Foultz, G. B.; Contreras, J. A.; Yee, S. S.; Arman, H. D.; Risinger, A. L.; Frantz, D. E. “Synthesis and Biological Evaluations of Electrophilic Steroids Inspired by the Taccalonolides.” ACS Med. Chem. Lett. 202011, 2534. Highlighted as a Supplementary Cover! Read it here!!

56. Munteanu, C. Spiller, T. E.; Qiu, J. DelMonte, A. J.; Wisniewski, S. R.; Simmons, E. M.; Frantz, D. E. “Pd- and Ni-Based Systems for the Catalytic Borylation of Aryl (Pseudo)halides with B2(OH)4.” J. Org. Chem. 2020, 85, 10334. Highlighted as a Featured Article! Read it here!!

55. Du, L.; Munteanu, C.; King, J. B.; Frantz, D. E.; Cichewicz, R. H. “An Electrophilic Natural Product Provides a Safe and Robust Odor Neutralization Approach to Counteract Malodorous Organosulfur Metabolites Encountered in Skunk Spray. J. Nat. Prod. 2019, 82, 1989. Read it here!!

The article was also highlighted in the August 5, 2019 issue of C&E News! Read it here!! 

54. Neff, R. K.; Frantz, D. E. "Cationic Alkynyl Heck Reaction toward Substituted Allenes Using BobCat: A New Hybrid Pd(0)-Catalyst Incorporating a Water-Soluble dba Ligand"  J. Am. Chem. Soc. 2018, 50, 17428Read it here!!

53. Stevens, J. M.; Parra Rivera, A.C.; Dixon, D. D.; Beutner, G. L.; Delmonte, A.; Frantz D. E.; Janey, J.M.; Paulson, J.; Talley, M. “Direct Lewis Acid-Catalyzed Conversion of Enantioenriched N-Acyl Oxazolidinones to Chiral Esters, Amides and Acids.”  J. Org. Chem. 201883, 14245. Highlighted as a Featured Article.  Read it here!!

52. El Arba, M.; Dibrell, S. E.; Meece. F.; Frantz, D. E. “Ru-Catalyzed Synthesis of Substituted Furans from Diazoacetates” Org. Lett. 201820, 5886.  Read it here!!

51. El Arba, M.; Dibrell, S. E.; Crouch, I. T.; Frantz, D. E. “Unified Approach to Substituted Allenoates via Pd-Catalyzed b-Hydride Elimination of (E)-Enol Triflates” Org. Lett. 201719, 5446.  Read it here!!

50. Munteanu, C.; Frantz, D. E. “Palladium-Catalyzed Synthesis of Alkynes via a Tandem Decarboxylation/Elimination of (E)-Enol Triflates” Org. Lett. 201618, 3937.  Read it here!!

49. Parra Rivera, A. C.; Still, R.; Frantz, D. E. “Iron-Catalyzed Stereoselective Cross-Coupling Reactions of Stereodefined Enol Carbamates with Grignard Reagents.” Angew. Chem. Int. Ed. 201655, 6689Read it here!!

Publications from 1996-2015:

48. Neff, R. K.; Frantz, D. E. “Recent applications of chiral allenes in axial-to-central chirality transfer reactions.” Tetrahedron, 2015 71, 7. Read it here!!

47. Peniche, A. G.; Osorio, Y.; Renslo, A. R.; Frantz, D. E.; Melby, P. C.; Travi, B. L. “Development of an ex vivo lymph node explant model for identification of novel molecules active against Leishmania major.” Antimicrobial Agents and Chemotherapy 2014, 58, 78.

46. Neff, R. K.; Frantz, D. E. “Recent advances in the catalytic syntheses of allenes: A critical assessment.” ACS Catalysis 2014, 4, 519. Invited Review. Read it here!!

45. Valentim, C. L. L.; Cioli, D.; Chevalier, R. D.; Cao, X.; Taylor, A. B.; Holloway, S. P.; Pica-mattoccia, L.; Guidi, A.; Basso, A.; Tsai, I. T.; Berriman, M.; Carvalho-Queirox, C.; Almeida, M.; Aguilar, H. A.; Frantz, D. E.; Hart, P. J.; LoVerde, P. T.; Anderson, T. J. C. “Genetic and molecular basis of drug resistance and species-specific drug action in Schistosome paratsites.” Science 2013, 342, 1385. Read it here!!

44. Risinger, A. l.; Peng, J.; Rohena, C. C.; Aguilar, H. A.; Frantz, D. E.; Mooberry, S. L. “The Bat Flower: A source of microtubule-destabilizing and –stabilizing compounds with synergistic antiproliferative actions.” J. Nat. Prod. 2013, 76,1923. Read it here!!

43. Wang, L; Chang, J.; Varghese, D.; Dellinger, M.; Kumar, S.; Best, A. M.; Ruiz, J.; Bruick, R.; Peña-Llopis, S.; Xu, J.; Babinski, D. J.; Frantz, D. E.; Brekken, R. A.; Quinn, A. M.; Simeonov, A.; Easmon, J.; Martinez, E. D. “A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth” Nat. Commun.2013, 4,2035. Read it here!!

42. Crouch, I. T.; Neff, R. K.; Frantz, D. E. “Pd-Catalyzed Asymmetric b-Hydride Elimination En Route to Chiral Allenes” J. Am. Chem. Soc. 2013, 135, 4970. Highlighted in the April 1stissue of Chemical and Engineering News.Highlighted by Synfacts. Read it here!!

41. Scheuermann, T. H.; Li, Q.; Ma, H. –W.; Key, J.; Zhang, L.; Chen, R.; Garcia, J. A.; Naidoo, J.; Longgood, J.; Frantz, D. E.; Tambar, U. K.; Gardner, K. H.; Bruick, R. K. “Allosteric Inhibition of Hypoxia Inducible Factor 2 with Small Molecules” Nature Chem. Bio. 2013, 9,271. Read it here!!

40. Rogers, J. L. Bayeh, L.; Scheuermann, T. H.; Longgood, J.; Caldwell, C.; Key, J.; Naidoo, J.; Melito, L.; Shokri, C.; Frantz, D. E.; Bruick, R. K.; Gardner, K. H.; MacMillan, J. B.; Tambar, U. K. “Development of Inhibitors of the PAS-B Domain of the HIF-2a Transcription Factor” J. Med. Chem. 2013, 56,1739. Read it here!!

39. Babinksi, D. J.; Bao, X.; El Arba, M.; Chen, B.; Hrovat, D. A.; Borden, W. T.; Frantz, D. E. “Synchronized Aromaticity as an Enthalpic Driving Force for t he Aromatic Cope Rearrangement” J. Am. Chem. Soc. 2012, 134, 16139. Read it here!!

38. Kato, M.; Han, T. W.; Xie, S.; Shi, K.; Du, X.; Wu, L. C.; Mirzaei, H.; Goldsmith, E. J.; Longggood, J.; Pei, J.; Grishin, N. V.; Frantz, D. E.; Schneider, J. W.; Chen, S.; Li, L.; Sawaya, M. R.; Eisenberg, D.; Tycko, R.; McKnight, S. L. “Cell-free formation of RNA granules: Low complexity sequence domains form dynamic fibers within hydrogels.” Cell, 2012, 149, 753-767. Read it here!!

37. Zang, Q. S.; Hesham, S.; Maass, D. L.; Martinez, B.; Ma, L.; Kilgore, J. A.; Williams, N. S.; Frantz, D. E.; Wigginton, J. G.; Nwariaku, F. E.; Wolf, S. E.; Minei, J. P. “Specific Inhibition of mitochondrial oxidative stress suppresses inflammation and improves cardiac function in a rat pneumonia-related sepsis model.” American Journal of Physiology-Heart and Circulatory Physiology, 2012, 302, H1847-H1859.

36. Russell, J. L.; Goetsch, S. C.; Aguilar, H. R.; Coe, H.; Luo, X.; Liu, N.; van Rooij, E.; Frantz, D. E.; Schneider, J. W. “Targeting Native Adult Heart Progenitors with Cardiogenic Small Molecules.” ACS Chemical Biology, 2012, 7, 1067. Read it here!!

35. Russell, J. L.; Goetsch, S. C.; Aguilar, H. R.; Frantz, D. E.; Schneider, J. W. “Regulated expression of pH sensing G protein-coupled receptor-68 identified through chemical biology defines a new drug target for ischemic heart disease.” ACS Chemical Biology, 2012, 7, 1077. Read it here!!

34. Hartley, R. M.; Peng, J.; Fest, G. A.; Dakshanamurthy, S.; Frantz, D. E.; Brown, M. L.; Mooberry, S. L.“Polygamain, a new microtubule depolymerizing agent that occupies a unique pharmacophore in the colchicine site.”  Mol. Pharm. 2012, 81, 431.

33. Mata, M. A.; Satterly, N.; Versteeg, G. A.; Frantz, D. E.; Wei, S.; Williams, N.; Schmolke, M.; Peña-Llopis, S.; Brugarolas, J.; Forst, C. V.; White, M. A.; Garcia-Sastre, A.; Roth, M. G.; Fontoura, B. M. A. “Chemical inhibition of RNA viruses reveals REDD1 as a host defense fact.” Nature Chem, Bio. 2011, 7,712-719.

32. Babinski, D. J.; Aguilar, H. A.; Still, R.; Frantz, D. E. “Synthesis of substituted pyrazoles via tandem cross-coupling/electrocyclization of enol triflates and diazoacetates.” J. Org. Chem.2011, 76,5915. (Featured Article and Highlighted by SYNFACTS)

31. Crouch, I. T.; Dreier, T.; Frantz, D. E. “Palladium-catalyzed elimination/isomerization of enol triflates into 1,3-dienes.” Angew. Chem. Int. Ed.2011, 50, 6128-6132.(Highlighted by SYNFACTS)

30. Wang, Y. X.; Zang, Q. S.; Liu, Z. J.; Wu, Q.; Maass, D.; Dulan, G.; Shaul, P. W.; Melito, L.; Frantz, D. E.; Kilgore, J. A.; Williams, N. S.; Terada, L. S.; Nwariaku, F. E. “Regulation of VEGF-induced endothelial cell migration by mitochondrial reactive oxygen species.” Am. J. Phys. Cell Phys. 2011,301, C695-C704.

29. Zhang, L.; Peng, L.; Hsu, T.; Aguilar, H. R.; Frantz, D. E.; Schneider, J. W.; Bachoo, R. M.; Hsieh, J. “Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression.”Differentiation2011, 81,233-242.

28. Peng, J.; Jackson, E. M.; Babinski, D. J.; Risinger, A. L.; Helms, G.; Frantz, D. E.; Mooberry, S. L. “Evelynin, a ctyotoxic benzoquinone-type retro-dihydrochalcone from Tacca chantrieri.” J. Nat. Prod. 2010, 73,1590.

27Menzel, K.; Machrouchi, F.; Bodenstein, M.; Alorati, A.; Cowden, C.; Gibson, A. W.; Bishop, B.; Ikemoto, N.; Nelson, T. D.; Kress, M. H.; Frantz, D. E. “Process development of a potent bradykinin 1 antagonist.” Org. Process Res. Dev.2009,13, 519.

26. Lee, J.; Sperandio, V.; Frantz, D. E.; Longgood, J.; Camilli, A.; Phillips, M. A.; Michael, A. J. “An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae.” J. Biol. Chem.2009, 284,9899.

25. Schneider, J. W.; Gao, Z.; Li, S.; Farooqi, M.; Tang, T., -S.; Bezprozvanny, I.; Frantz, D. E.; Hsieh, J. “Small-molecule activation of neuronal cell fate.” Nature Chem. Bio.2008, 4,408.

24. Babinski, D.; Soltani, O.; Frantz, D. E. “Stereoselective synthesis of acetoacetate-derived enol triflates.” Org. Lett.2008, 10, 2901.

23. Sadek, H.; Hannack, B.; Choe, E.; Wang, J.; Latif, S.; Garry, M. G.; Garry, D. J.; Longgood, J.; Frantz, D. E.; Olson, E. N.; Hsieh, J.; Schneider, J. W. “Cardiogenic small molecules that enhance myocardial repair by stem cells.” Proc. Natl. Acad. Sci. U.S.A.2008, 105, 6063-6068.

22. Menzel, K.; Mills, P. M.; Frantz, D. E.; Nelson, T. D.; Kress, M. H. “Substitution effect on the regioselective halogen/metal exchange of 3-substituted 1,2,5-tribromobenzenes.” Tetrahedron Lett.2008, 49, 415-418.

21. Chen, X.; Longgood, J. C.; Michnoff, C.; Wei, S.; Frantz, D. E.; Bezprozvanny, I. “High-throughput screen for small molecule inhibitors of Mint1-PDZ domains.” Assay and Drug Development Technologies, 2007,5,769-784.

20. DiMichele, L.; Menzel, K.; Mills, P.; Frantz, D. E.; Nelson, T. D. “Halogen-metal exchange of 3-substituted 1,2-dibromoarenes: The use of long-range J(CH) coupling constants to determine regiochemistry.” Magn. Reson. Chem.2006, 44,1041-1043.

19. Menzel, K.; Fisher, E. L.; DiMichele, L.; Frantz, D. E.; Nelson, T. D.; Kress, M. H. “An improved method for the bromination of metalated haloarenes via lithium, zinc transmetalation: A convenient synthesis of 1,2-dibromoarenes.” J. Org. Chem.2006, 71,2188-2191.

18. Menzel, K.; DiMichele, L.; Mills, P.; Frantz, D. E.; Nelson, T. D.; Kress, M. H. “Regioselective halogen-metal exchange reaction of 3-substituted 1,2-dibromo arenes: The synthesis of 2-substituted 5-bromobenzoic acid.” Synlett 2006,12,1948-1952.

17. Nelson, T. D.; LeBlond, C. R.; Frantz, D. E.; Matty, L.; Mitten, J. V.; Weaver, D. G.; Moore, J. C.; Kim, J. M.; Boyd, R.; Kim, P.-Y.; Gbewonyo, K.; Brower, M.; Sturr, M.; McLaughlin, K.; McMasters, D. R.; Kress, M. H.; McNamara, J. M.; Dolling, U. H. “Stereoselective synthesis of a potent thrombin inhibitor by a novel P2-P3 lactone ring opening.” J. Org. Chem. 2004, 69, 3620-3627.

16. Faessler, R.; Tomooka, C. S.; Frantz, D. E.; Carreira, E. M. “Infrared spectroscopic investigations on the metallation of terminal alkynes by Zn(OTf)2.”Proc. Natl. Acad. Sci. U.S.A.2004, 101, 5843-5845.

15. Frantz, D. E.; Morency, L.; Soheili, A.; Murry, J. A.; Grabowski, E. J. J.; Tillyer, R. D. “ Synthesis of substituted imidazoles via organocatalysis.” Org. Lett. 2004, 6, 843-846.

14. Frantz, D. E.; Weaver, D. G.; Carey, J. P.; Kress, M. H.; Dolling, U. H. “Practical synthesis of aryl triflates under aqueous conditions.” Org. Lett. 2002,4,4717-4718.

13. Fassler, R.; Frantz, D. E.; Oetiker, J.; Carreira, E. M. “First synthesis of optically pure propargylic N-hydroxylamines by direct, highly diastereoselective addition of terminal alkynes to nitrones.”Angew. Chem. Int. Ed. 2002.41, 3054-3056.

12. Boyall, D.; Frantz, D. E.; Carreira, E. M. “Efficient enantioselective additions of terminal alkynes and aldehydes under operationally convenient conditions.” Org. Lett., 2002, 4, 2605-2606.

11. Frey, L. F.; Marcantonio, K.; Frantz, D. E.; Murry, J. A.; Tillyer, R. D.; Grabowski, E. J. J.; Reider, P. J. “Practical routes toward the synthesis of 2-halo and 2-alkylamine-4-pyridinecarboxaldehydes.” Tetrahedron Lett.2001, 42,6815-6818.

10. Murry, J. A.; Frantz, D. E.; Soheili, A.; Tillyer, R. D.; Grabowski, E. J. J.; Reider, P. J. “Synthesis of alpha-amido ketones via organic catalysis: Thiazolium-catalyzed cross-coupling of aldehydes with acylimines.” J. Am. Chem. Soc.2001,123, 9696-9697.

9. Frantz, D. E.; Fassler, R.; Tomooka, C. S.; Carreira, E. M. “The discovery of novel reactivity in the development of C-C bond-forming reactions: In situ generation of zinc acetylides with Zn(II)/R3N.” Acc. Chem. Res.2000; 33,373-381

8. Aschwanden, P.; Frantz, D. E.; Carreira, E. M. “Synthesis of 2,3-dihydroisoxazoles from propargylic N-hydroxylamines via Zn(II)-catalyzed ring-closure reaction.” Org. Lett.2000, 2, 2331-2333.

7. Frantz, D. E.; Singleton, D. A. “Isotope effects and the mechanism of chlorotrimethylsilane-mediated addition of cuprates to enones.” J. Am. Chem. Soc.2000, 122, 3288-3295.

6. Boyall, D.; Lopez, H.; Sasaki, H.; Frantz, D. E.; Carreira, E. M. “Enantioselective addition of 2-methyl-3-butyn-2-ol to aldehydes: Preparation of 3-hydroxy-1-butynes.” Org. Lett.2000, 2, 4233.

5. Frantz, D. E.; Faessler, R.; Carreira, E. M. “Facile enantioselective synthesis of propargyl alcohols by direct addition of terminal alkynes to aldehdyes.” J. Am. Chem. Soc.2000, 122, 1806-1807.

4. Frantz, D. E.; Faessler, R.; Carreira, E. M. “Catalytic in situ generation of Zn(II)-alkynilides under mild conditions: A novel C=N addition process utilizing terminal acetylenes.” J. Am. Chem. Soc. 1999, 121, 11245-11246.

3. Frantz, D. E.; Singleton, D. A. “Carbometalations of simple alkenes with allyldibromoborane.” Org. Lett.1999, 1,485-486.

2. Frantz, D. E.; Singleton, D. A.; Snyder, J. P. C-13 kinetic isotope effects for the addition of lithium dibutylcuprate to cyclohexenone. Reductive elimination is rate-determining.” J. Am. Chem. Soc.1997, 119,3383-3384.

1. Singleton, D. A.; Waller, S. C.; Zhang, Z.; Frantz, D. E.; Leung, S.-W. “Allylboration of alkenes with allyldihaloboranes.” J. Am. Chem. Soc.1996, 118,9986-9987.