Dr. Michael P. Doyle
Professor and The Rita and John Feik Distinguished University Chair in Medicinal Chemistry
Office: BSE 1.104G
Phone: (210) 458-4196
Email: michael.doyle@utsa.edu
ResearcherID: http://www.researcherid.com/rid/C-3367-2009
Areas of Research
- Asymmetric Lewis Acid Catalysis
- Bioorganic Chemistry of Arenediazonium Salts
- Bioinorganic Chemistry of Nitrogen Oxides and Nitrosyls
- Carbocation Chemistry
- Carbon-Hydrogen Insertion
- Catalytic Asymmetric Cycloaddition
- Catalytic Enantioselective Hetero-Diels-Alder Reactions
- Catalytic Hydroformylation
- Catalytic Hydrosilylation and Silylcarbonylation
- Catalytic Oxidation Processes
- Chemistry of Diazo Compounds
- Cyclopropane Chemistry
- Design and Development of Chiral Catalysts
- Dirhodium(III) Materials
- Enantioselective Syntheses
- Formation and Reactions of Diazonium Ions
- Gold Catalysed Reactions
- Highly Enantioselective Catalytic Reactions
- Macrolide Formation in Catalytic Metal Carbene Reactions
- Mechanisms for Catalysis
- Metal Carbene Chemistry
- Organosilane Reductions
- Metal Carbene [3+n] Reactions
- Selective Chemical Oxidations
- Ylide Formation/Reactions
Education
Postdoctoral Associate and Instructor, University of Illinois at Chicago Circle, Chicago, Illinois (1968) — Postdoctoral advisor: Jan Rocek
Ph.D., Iowa State University, Ames, Iowa (1968) — Thesis advisor: Walter S. Trahanovsky
B.S., College of St. Thomas, St. Paul, Minnesota (1964)
Employment
- Professor and The Rita and John Feik Distinguished University Chair in Medicinal Chemistry
- Professor, Department of Chemistry and Biochemistry
- 2003-2013: Department Chair
- 2010-2013: Member, Administrative Council for College of Computer, Mathematical, and Natural Sciences
- 2003-2010: Member, Administrative Council for College of Chemical and Life Sciences
- Professor, Department of Chemistry
- 2002: Member, Executive Committee
- 2002: President
- 1997-2001: Vice President
- Dr. D. R. Semmes Distinguished Professor of Chemistry
- 1982-1984: Kenneth G. Herrick Professor of Chemistry
- 1976-1979: Chairman
- 1974: Professor
- 1971: Associate Professor
- 1968: Assistant Professor
Extramural Experience
- Metal Carbene Consortium: Founding Member (2014 – present) and Principal Organizer for the Third International Symposium of the Metal Carbene Symposium: Symposium on Carbene and Nitrene Chemistry.
- Metal Carbene Consortium: Founding Member (2014 – present) and Principal Organizer for the Third International Symposium of the Metal Carbene Symposium: Symposium on Carbene and Nitrene Chemistry.
- Member, Joint Board-Council Committee on Publications (2014-2016); Associate Member (2012)
- Editorial Board for C&E News (2014-2016)
- Member, Commission on Graduate Education in the Chemical Sciences (2012)
- Associate Member, Budget and Finance Committee (2012-2013)
- General Chair, 2011 Middle Atlantic Regional Meeting of the American Chemical Society, University of Maryland, College Park, MD (May 21-24, 2011)
- Member, Executive Committee for the Division of Organic Chemistry (1988-1990, elected office); Councilor (1990-2011, elected office); Chairman-Elect (1992); Chairman (1993); Past-Chairman (1994)
- Chairman, Joint Board-Council Committee on Publications (1997-1999); consultant (2000-2001)
- Chair, Editorial Board for C&E News (1997-1999)
- Member, Committee on Science (1995-2003); Associate Member (1993-94)
- Member, Committee on Committees (1996-1998, elected by Council)
- Member, Committee on Nominations and Elections (1993; 2002-2007; elected by Council)
- Member, ACS Task Force to Monitor C&E News (1993)
- Member, Board Implementation Task Force on Minorities (1991-1992)
- Chairman, Membership Affairs Committee (1990-1992)
- Member, Board of Trustees, Group Insurance Plans (1990-1992)
- Member, Committee on Professional Training (1985-1990)
- Member, Joint COMSCI, CPT, SOCED Task Force on Research and Teaching (1989)
- Member, Ad Hoc Task Force to Monitor Chemical and Engineering News (1986)
- Chairman of the Task Force on Awards in Undergraduate Education, Division of Chemical Education (1983-1987)
- Member, Program Committee, Division of Chemical Education (1982-1988)
- Program Co-chairman for the Fall 1987 National ACS Meeting in New Orleans, Division of Chemical Education
- Program Co-chairman for the Joint Central and Great Lakes Regional ACS Meeting in Kalamazoo, MI (May 23-25, 1984)
- Councilor (2013-2015); President-Elect (2010); President (2011); Past President (2012)
- Member, Board of Managers
- Chair or member of several committees
- Co-Chair, Scientific Committee for 2012 IChO at the University of Maryland
- Advisory Council (2016-present)
- Member, JIFSAN Working Group (joint with Food and Drug Administration) (2010-2014)
- Member, Advisory Board, Program Committee (2008-2010)
- Titular Member and Secretary, Commission on Physical Organic Chemistry (III.2) (1987-1991)
- Associate Member, Commission on Physical Organic Chemistry (III.2) (1979-1987)
- Co-organizer, NSF Workshop on Undergraduate Research Centers (September 17, 2004)
- Member, Committee of Visitors, Division of Chemistry (March 1998; May 2010)
- Co-chairman, Workshop on Undergraduate Education in Chemistry, SEE Directorate/ Chemistry Division of MPS Directorate (May 1988)
- Member, Chemistry Division Advisory Committee (1982-1985)
- Member, NSF Panel for Research Facilities Awards (September 1990)
- Member, Chemistry Division Panel for Presidential Young Investigator Award proposals (January 1988; December 1988; February 1990)
- Member, Chemistry Division Panel for Research Experiences for Undergraduates (REU) awards (December 1988)
- Member, Chemistry Panel for Instructional Laboratory Improvement (ILI) Program (January 1989)
- Member, Ad Hoc Committee on Exploratory Research Grants (March 1989)
- Member, Committee on Evaluation of Macro-ROA Activities and Recommendations for Future Undergraduate Research Participation (December 1986)
- Member, Workshop on Undergraduate Science Education (June 1986)
- Member, Ad Hoc Review Group for Evaluation of the Research in Undergraduate Institutions (RUI) Program (December 1984)
- Member, National Science Foundation Chemistry Division Advisory Committee (1982-1984)
- Member, Ad Hoc Panel for review of Proposals for the Regional Instrumentation Program (June 1978)
- Member, BCST “Challenges in Graduate Education: A Workshop” (January 2012)
- Member, Chemical Sciences Roundtable (2000-2004) and Member of its Executive Committee
- Co-organizer, CSR Workshop and Report on “Preparing Chemists and Chemical Engineers for a Globally Oriented Workforce” (October 2003)
- Member, Committee on Career Paths for Graduates in the Physical Sciences and Mathematics (Planning Group, 1995)
- Member, Board on Chemical Sciences and Technology (1990-1994)
- Member, Committee on Undergraduate Science Education (1993-1996)
- Member, Workshop on “The Chemistry Department of the Future,” Washington, D.C. (August 1987)
- Member, Board of Directors (1989-1997; 2000-2002)
- Member, Cottrell Program Advisory Committee (1978-1983)
- Invited participant to the Conference on Research at the Undergraduate Level, Callaway Gardens, GA (April 1975)
- Foundation Advisor (1989-1997)
- Ad Hoc Member, Peer Review of Fellowship Applications – Oncology 1-Basic Translational (OBT) IRG (April 2013)
- Member, Medicinal Chemistry Study Section A (2003-2004); Synthetic and Biological Chemistry A Study Section (2005-2007)
- Ad Hoc Member, National Advisory General Medical Sciences Council (January 1992; January 2001)
- Ad Hoc Member, Medicinal Chemistry Study Section (June 1985; February 1987; October 1989; Chairman, November 1993)
- Member-at-Large, Chemistry Section (2015-2018)
- Fellow (1995)
- Nominating Committee for Chemistry Section (1999-2001)
- Member, Executive Committee (2009-2010)
- Member, Board of Directors (2008-2010)
- Councilor (1978-1990; 1991-1994); Chairman (1987-1989); President (1978-1983); Editor of the CUR Newsletter (1978-1993)
- Coordinator of Academic-Industrial Undergraduate Research Partnership Program (AIURP) (1987-1997)
- Organized the Spring Hill Conference on “Critical Issues Influencing Undergraduate Research at Predominantly Undergraduate Institutions” and obtained funding for conference participants (July 1983)
- Member, National Advisory Board (1985-1988); Chairman, Executive Committee (1987-1988)
- Member, Governing Board (1989-1993)
- Chairman, Steering Committee for the Third National Conference at Trinity University (April 1989)
- Chairman of Chemistry Panel 2 for the evaluation of long-term grants to the Former Soviet Union (December 1993; July 1994)
- Member RGC (2015-2020)
- Deputy Convenor, RAE for Physical Sciences (2005-2006; 2013-2014)
- Member, RAE Group (2017-2020)
- American Chemical Society
- American Association for the Advancement of Science
- International Society of Heterocyclic Chemistry
Editorial Boards
- Chinese Chemical Letters, Editorial Board Member (2013-present)
- The Chemical Record, International Advisory Board (2010-present)
- Chemical Communications, Associate Editor (2007-2010); Member of Editorial Board
- Chemical & Engineering News (Advisory Board, 2005-2011; Editorial Board, 1997-1999 (Chair), 2014-present)
- Advanced Synthesis and Catalysis, Editorial Advisory Board (2000-2010)
- Organic Letters, Editorial Advisory Board (1999-2014)
- Accounts of Chemical Research, Editorial Advisory Board (1999-2013); Guest Editor for “C-H Functionalization” Issue (2012)
- Concepts in Magnetic Resonance, Editorial Board (1995-2000)
- Russian Chemical Bulletin, International Advisory Board (1995-present)
- CUR Newsletter Editor (1978-1993)
Honors and Awards
- Henry J. Albert Award sponsored by BASF Corporation, International Precious Metals Institute (2020)
- Certificate of Advancing Globalization, UTSA College of Science (2016)
- Hillebrand Award, Chemical Society of Washington (2014)
- 2011 NOBCChE Presidential Award for Outstanding Partner in Academia (2011)
- Faculty Minority Achievement Award, University of Maryland, President’s Commission on Ethnic Minority Issues (2010)
- Fellow, American Chemical Society (2009)
- Ida Cordelia Beam Distinguished Visiting Professor in Chemistry, University of Iowa (2009)
- Fellow, Royal Society of Chemistry (2009)
- Edward Leete Award from the ACS Division of Organic Chemistry (2007)
- Outstanding Chemistry Alumni Award, Iowa State University (2006)
- Arthur C. Cope Senior Scholar Award from the American Chemical Society (2006)
- Harry and Carol Moser Award from the Santa Clara Valley Section of the ACS (2005)
- Guest Professorship, Nankai University, Tianjin, PRC (2004)
- Merit Award, National Institutes of Health (2003)
- George C. Pimentel Award in Chemical Education of the American Chemical Society (2002)
- Gilman Research Award from the Department of Chemistry, Iowa State University (2001)
- Paul G. Gassman Distinguished Service Award from the ACS Division of Organic Chemistry (1998)
- Japan Society for the Promotion of Science (JSPS) Invitation Fellowship (1996)
- James Flack Norris Award for Outstanding Achievements in the Teaching of Chemistry, Northeastern Section of the American Chemical Society (1995)
- Alexander von Humboldt Senior Research Award for U.S. Scientists, Alexander von Humboldt Foundation (1995)
- Fellow, American Association for the Advancement of Science (1995)
- Doctor Honoris Causa of the Russian Academy of Sciences (election March 1994)
- American Chemical Society Award for Research at Undergraduate Institutions sponsored by the Research Corporation (1988)
- Chemical Manufacturers Association Catalyst Award (1982)
- Observer for IUPAC Assembly in Warsaw, Poland, National Research Council Selection (August 1977)
- Camille and Henry Dreyfus Foundation Teacher-Scholar Award (1973)
- U.S. Public Health Service Fellow, Iowa State University (1966-67)
Selected Research Contributions
- Gold-catalyzed Reactions (2013-present)
- Catalytic Enantioselective [3+n]-Cycloaddition Reactions (2011-present)
- Dirhodium(III,III) Organometallic Compounds (2007-present)
- Catalytic Oxidations (2004-present)
- Enantioselective Lewis Acid Catalyzed Reactions (2000-present)
- Macrocyclization via Metal Carbene Intermediates (1995-2006)
- Highly Enantioselective Dirhodium(II) Catalysts (1990-present)
- Catalytic Hydrosilylation, Silylcarbonylation, and Hydroformylation (1990-1994)
- Carbenes Generated From Diazirines (1984-1989)
- Selective Catalysts for Metal Carbene Transformations (1980-present)
- Nitrosyl Chemistry of Hemoproteins, including mechanism of nitrite oxidations (1980-1991)
- Nickel(II) Promoted Alcohol Oxidations (1979-1981)
- Lewis Acid Promoted Reactions of Diazocarbonyl Compounds (1978-1982)
- Alkyl Nitrite-Metal Halide Deamination Reactions (1976-1980)
- Organosilane Reductions in Acidic Media (1971-1978)
- Nitrosonium and Nitronium Ion Chemistry (1968-1979)
Selected Professional Accomplishments
- Journal Publications: more than 390; 51 since 2014; h-index 73; more than 21,000 citations; 46+ average citations per article
- Patents: 11
- Book Chapters: 24; 4 since 2012
- Books: 11
- Invited Lectures: more than 40 since 2014
- Education: More than 170 undergraduate co-authors of research publications
- Research:
- Developed direct conversion of arylamines for Sandmeyer, Merwein, and related reactions
- Developed organosilane reductions of organic compounds
- Provided current mechanistic understanding of nitrite oxidations of heme proteins and the role of nitric oxide; HNO chemistry
- Chiral dirhodium carboxamidate catalysts (Doyle catalysts) and their applications in metal carbene and Lewis acid transformations (e.g., www.sigmaaldrich.com/-catalog/product/aldrich/424420)
- Ylide reactions through metal carbenes (“Doyle-Kirmse Reaction”-wikipedia.org/wiki/Doyle-Kirmse reaction)
- Dirhodium catalyzed allylic oxidations-the “Umera-Doyle reaction” [in “Organic Synthesis Based on Name Reactions” by C. Stumer and A. Hassner, Elsevier, 2012]
- Catalytic asymmetric cycloaddition reactions
- First President of Council on Undergraduate Research (CUR) and first Chairman of the National Conferences on Undergraduate Research (NCUR)
- Co-Chair, Scientific Committee for the 2012 International Chemistry Olympiad