Ms. Yifan Wang from Dr. Liu’s Lab Published in the Proceedings of the National Academy of Sciences

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Ms. Yifan Wang and other graduate students in Dr. Liu’s laboratory used a single-crystal EPR spectroscopy and X-ray crystallography to determine intermediates and high-resolution crystal structure of key dioxygenase enzyme involved in tryptophan metabolism and NAD+ biosynthesis.  Their work, including the enzyme action movie, has been published in the Proceedings of the National Academy of Sciences (DOI: 10.1073/pnas.2005327117).  It has the potential to provide new targets for drug development.  “This has been a massive effort.  Yifan and others have worked on this project tirelessly for many years,” said Dr. Liu, Yifan’s advisor.  Yifan is also a co-author on other Liu’s papers published recently in  Chem. Soc. Rev., JBC,  Angew. Chem., ACS Catal. (Editor’s Choice article), Nat. Chem. Biol., and JACS.  Her publication record reflects the high-quality training she has received in the Chemistry Department of UTSA. 

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